Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women that affects 15-20% of women, which is directly related to insulin resistance (IR). PCOS is diagnosed with two of the three symptoms of ovarian cyst, oligomenorrhea and hyperandrogenism. Factors such as adiponectin and APPL-1 play a role in IR signaling, which are reduced by PCOS. The signaling pathway of insulin resistance, adiponectin and APPL1 are affected by metabolism and exercise. The present study was conducted with the aim of the effect of six weeks of swimming training on the expression of adiponectin and APPL-1 genes in the liver of rats with polycystic ovary syndrome.
Methods: This experimental research was conducted on 36 female wistar rats. The rats were divided in six groups. Swimming training was done (six weeks/five days a week, 60 min each session/ flow of the water speed was increased from seven to 15 L/M). After 24hr of sacrifices the mice, the expression of adiponectin and APPL1 genes were measured in the liver tissue. Data were analyzed using SPSS software (version 22) and two-way ANOVA. P< .005 was considered statistically significant.
Results: Six weeks of training had a significant effect on adiponectin gene expression (P=0.004), while it had no significant effect on APPL-1 gene expression (P=0.433).
Conclusion: Our result show that six weeks of swimming training can lead to significant changes in expression of adiponectin gene. It seems that APPL1 have not increase during the six weeks of swimming training. Although swimming have positive effects in PCOS patients by improving the metabolic pathway.