Introduction: Appropriate approaches and management are prerequisites for modifying mortality in gastric cancer (GC) patients. On the other hands, Some susceptibility causative mRNAs-lncRNAs distinguished in gastric cancer are powerfully related to different approaches. While several pathomechanisms are involved in GC, the vital mRNA-lncRNAs are not elucidated. Insufficiency of effective drugs and the refractory cancerous cells to the existing medicines challenge GC treatment. Exercise training can be practical in the primary prevention of cancers.
Methods: Microarray data and protein-protein interactions network analysis might identify genes and proteins having the highest consequence during pathogenesis by analyzing the network's parameters such as degree, betweenness centrality, closeness centrality, and eigenvector. Mice were divided into Five groups (n=30), including Control, mice treated with N-methyl-N-nitrosourea (MNU) (244 ppm, 18 weeks, gastric cancer group), gastric cancer mice consumed Paclitaxel (GC+Paclitaxel), GC mice received Paclitaxel and exercise training with moderate intensity (GC+Chem+EX), GC+EX. The expression level of the genes was measured via qPCR Real-Time.
Results: Artificial intelligence has explored the critical mRNA-lncRNAs related to the gastric cancer. We found that the IL10, IL8, SPP1, LOX, and COL1A1 expression levels improved in GC+Chem+EX and GC+EX. Although the expression level of the IL10, IL8, and SPP1 enhanced, the level of the LOX and COL1A1 decreased. The relative expression of the M1201396 lncRNA regulated by exercise training. M1201396 dexreased and enhanced in GC and GC+Chem+EX, respectively.
Conclusion: Exercise training might be considered complementary and alternative strategies for preventing and treating GC. We found that the mitigated the side effects of the Paclitaxel.