Different treatment strategies have been proposed over time in order to improve RA patients’ quality of life, to reduce anxiety and depression, pain and increase mobility. Corticosteroids are the most commonly used anti-inflammatory treatment for chronic diseases such as rheumatoid arthritis, but their long-term use is associated with increased side effects, including hyperglycemia and insulin resistance, which are common in people treated with these drugs. Therefore, in this study, we examined the effect of nonpharmacological treatments. Methods. The study population was included 100 patients with RA attending a rheumatology service of the “Shariati Hospital” in Tehran. To be eligible for the study, patients had to be 40-60 years and to have met the American College of Rheumatology criteria and prediabetes symptoms. Twenty RA patients were studied randomly divided into two groups, Exercise and Supplement. The exclusion criteria for both groups were previous or current smoking history, ischemic CVD, hypertension, diabetes mellitus, thyroid disease, renal impairment, hepatic disease, and hyperlipidemia. We also excluded patients previously treated with high doses of steroids (>10 mg/day prednisone or equivalent). A structured questionnaire was applied to each patient in order to evaluate demographic and clinical variables including disease duration and treatment. The training programs consist for 2 months, three sessions a week. ‌Supplement and exercise+ supplement groups consumed 1.3 gr Celery seeds three times a day after meals and the exercise+ placebo group also consumed the same amount of starch. In order to evaluate biochemical variables, blood sampling was done after 12 hours fasting and in two stages, one day before the start of training and after the last training session. levels of blood glucose and HbA1c were measured. Variables were tested for normality using the Kolmogorov-Smirnov test. All data were analyzed using SPSS 25.0 software and group differences were estimated by paired-sample t-test and ANOVA test. Results. The present study found that combined protocol improved FBS in exercise+ supplement group (p<0.05) in patients with RA and no significant change was observed in the levels of HbA1c in exercise group (p≥0.05). It seems that the combined protocols include exercise and herbal supplements can moderate the side effects of chemical drugs in patients with rheumatoid arthritis.