Introduction: High-intensity interval training (HIIT) has gained recognition for its profound impact on physiological adaptations, including oxidative stress and antioxidant defense mechanisms. This study review aims to systematically examine the existing literature on the effects of HIIT on antioxidant enzymes and oxidative stress markers. Understanding the influence of HIIT on antioxidant capacity is essential for elucidating the role of exercise in modulating redox balance and cellular health.
Methodology: A comprehensive review of studies investigating the effects of HIIT on antioxidant enzymes was conducted. Peer-reviewed articles were identified through systematic searches of electronic databases, focusing on interventions utilizing HIIT protocols and assessing changes in antioxidant enzyme activity and oxidative stress markers. Data extraction and synthesis were performed to analyze key findings, methodological approaches, and trends across the selected studies.
Results: The review of studies revealed that HIIT interventions elicit significant changes in antioxidant enzyme activity, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). HIIT was found to enhance the expression and activity of these antioxidant enzymes, leading to improved cellular defense against oxidative damage. Additionally, HIIT was associated with reductions in oxidative stress markers, indicating a more favorable redox balance following exercise training.
Conclusions: The findings from this study review suggest that HIIT plays a crucial role in upregulating antioxidant enzyme systems, thereby enhancing cellular antioxidant capacity and mitigating oxidative stress. The modulation of antioxidant enzymes by HIIT may contribute to improved redox homeostasis, reduced oxidative damage, and enhanced overall cellular resilience. Incorporating HIIT into exercise regimens could be a promising strategy for promoting antioxidant defense mechanisms and supporting cellular health.