Aging is a natural phase of life characterized by physiological changes, including decreased activity levels, muscle mass weakness, alterations in bone density, and cognitive impairments. However, these age-related factors can be positively influenced by modifying daily lifestyle, leading to potential improvements in elderly individuals. Extensive research has explored pharmaceutical and non-pharmacological interventions, but recent studies consistently demonstrate the positive outcomes of incorporating physical activities into the lifestyles of older adults. Physical activity has proven to be an effective approach for enhancing muscle strength, balance, and memory in both elderly and very elderly populations. Furthermore, the use of complementary interventions alongside physical activity to further enhance the alleviation of aging symptoms and reduce disability rates is of significant importance. Creatine, a nitrogen-containing compound found naturally in various tissues of the body and commonly used as a dietary supplement, has shown promising results when combined with resistance training, resulting in greater adaptive responses in skeletal muscles compared to isolated resistance exercise. Moreover, creatine supplementation may also exert a positive influence on the aging process. Recent studies investigating the combined effects of physical activity and creatine supplementation have demonstrated improvements in overall physical health, muscle function and cognitive abilities across different age groups of older individuals. Additionally, limited changes in bone density have been observed in this population. Therefore, the purpose of this review is to comprehensively summarize recent studies focusing on the effects of resistance training in conjunction with creatine supplementation on physical health, muscle, bone, and cognitive function in older adults.