Abstract
Introduction: Diabetes is a metabolic disease that is associated with increased blood sugar and disruption of energy homeostasis in the body. The release of adipokines from adipose tissue plays a key role in regulating metabolic metabolism and several other physiological processes, including diabetes, obesity, and cardiovascular diseases. In this study, the effect of six weeks of aerobic exercise on asprosin and insulin resistance in male diabetic rats was investigated.
Methods: 32 male Wistar rats were randomly divided into four groups: control (C), healthy + exercise (H+T), diabetes (D), diabetes+exercise (D+T). Induction of diabetes was done by injecting a single dose of streptozotocin (STZ) in the amount of 45 Mg/Kg intraperitoneally. Data were analyzed using one-way ANOVA and Bonferroni test at a significance level of 0.05.

Findings: Induction of diabetes caused an increase in plasma asprosin in the diabetic group compared to the control (healthy) group, and after six weeks of aerobic exercise in the control+exercise and diabetes+exercise groups, there was a significant decrease compared to the control and diabetes groups (0001). /0P=). Also, the amount of LDL in the healthy + exercise group was significantly reduced compared to the control (P=0.0001). The amount of HDL also increased significantly in the healthy + exercise group compared to the control (P=0.0001), which indicates that continuous aerobic activity had a significant effect in the exercise groups. However, there was no significant decrease in the amount of TG after training.

Conclusion: The results of the present study showed that six weeks of continuous aerobic training can reduce plasma asprosin levels, insulin resistance, LDL; increase HDL and in general have a significant improvement on the lipid profile of type 2 diabetic male rats.