The only adapted football modality present in the Paralympic Games is five-a-side football (Fa5) or blind football, whose regulations are ruled by the International Federation of Associated Football. Sports injuries, some head impacts and PA factors seem to be engaged in this sport. The purpose of this review is to investigate the prevalence of sports injuries, cervical muscle characteristics and physical fitness in blind football players. A comprehensive review of investigating the prevalence of sports injuries, cervical muscle characteristics and physical fitness in blind football players was done by searching the Google Scholar, PubMed, Science Direct, Web of Science and Scopus databases with the keywords five-a-side football OR blind football AND physical activity OR physical fitness OR sports AND neck muscles OR cervical muscle characteristics OR head impact AND injury OR sports injuries. In the initial search, 20 articles were found, which 5 duplicate articles were removed. In the second part of screening, based on the inclusion criteria, 5 articles unrelated to the subject were also excluded from the scope of the review, and finally, based on the standard principles and the title of the present study, the current study was done with 10 papers. According to the research findings, Blind Association Football has the highest rate of injury of any Paralympic sport and head injuries are common. Regular physical activity (PA) increases exercise capacity and physical fitness (PF), which can lead to many health benefits in blind football players. Fa5 at the had the highest incidence of sports injuries in different Paralympic games that this may be due to the high load and intensity of training, the game’s characteristics, the players’ qualities and the reduced size of the field. In conclusion, this review revealed that blind football can negatively affect some cervical muscle characteristics and sports injuries especially in lower body and positively can influence on some physical fitness factors.