In the World Health Charter, a person's health means his complete physical, mental and social security. Based on this, one of the three important pillars of human health is mental health, which in interaction with physical and social health causes overall health. Psychological adjustment is one of the most important factors in the success of athletes. therefore; The aim of this study was to determine the mediating role of sports perfectionism in the relationship between general health and psychological adjustment of professional athletes in West Azerbaijan province. The research method in this study was descriptive-correlational and the statistical population of this study was all professional athletes in West Azerbaijan province in 2021 that 255 athletes were selected using Cochran's formula and simple random sampling. Data were collected using standard questionnaires of Dan et al. (2005), Goldberg & Hiller (1979) mental health and Clark (1939) psychological adjustment scale and analyzed using SPSS software and descriptive and inferential tests. In this study, the data were analyzed at the alpha level of 0.05. The results of the hypotheses with Pearson correlation test showed that there is a significant relationship between general health and its components with psychological adjustment of athletes. There is a significant relationship between sports perfectionism and psychological adjustment of professional athletes of West Azerbaijan province. Sports perfectionism also mediates the relationship between general health and psychological adjustment of athletes. The results of multivariate regression analysis showed that general health and sports perfectionism are effective in predicting the psychological adjustment of professional athletes.