Introduction: Polycystic ovarian syndrome (PCOS) is one of the most important reproductive and endocrine disorders. Lifestyle modification, including increased physical activity, is the first approach in managing PCOS. The aim of this study was to examine the effect of aerobic training with different intensities on liver enzymes and coagulation in female rats with polycystic ovary syndrome (PCOS).
Methods and Materials: 40 female Wistar rats (180±20mg) with 2 to 3 consecutive estrous cycles during12 to 14 days were selected. The first two groups were divided into Healthy control (HC) (n=10) and polycystic (n=30) that got sick by estradiol valerate injection after 60 days. The polycystic groups were divided into three groups of Polycystic control (PCOSC), Low-intensity exercise (PCOS-LIE) and Moderate intensity exercise (PCOS-MIE). Exercises were performed in 6 sessions of 60 minutes per week for 8 weeks. The mice were anesthetized by injection of 5 ml of blood directly from the heart and the blood factors were measured through Elisa.
Results: The results showed that there was no significant difference between the mean values of aspartate transaminase in female rats in different groups (P=0.057). Also, there was no significant difference between the mean values of alkaline phosphate in female rats in different groups (P=.104). However, variations in prothrombin time of female rats in the low intensity training group were significantly reduced compared to the moderate intensity training group (P=0.008).
Conclusion: The inadequacy of the intervention period (frequency and intensity of exercise) can be one of the possible causes of the ineffectiveness of training on these variables.