Background: Aging is an irreversible and indispensable risk factor that follows a continuous degradation process alongside with declines in physical functions and abilities. Fortunately, many researches have been conducted that show physical activity plays a critical role in healthy aging, increasing lifespan and quality of life by reducing the incidence of chronic physical and mental diseases. Objectives: To analyse the effect of six weeks of total body resistance exercises (TRX) on the strength and agility of cognitively healthy elderly women. Methodology: 32 healthy older women (+60 yrs) were answered to MMSE questions so as to their mental cognitive health to be investigated followed by blood tests for physical health. Participants randomly selection from Geriatric Center, Shahid Rajaee Teacher Training University, Tehran, Iran were divided into 2 experimental groups (n=17) and control group (n=15). Before starting the exercises, Fullerton functional tests were performed by groups in order to measure upper and lower body strength and agility. The training protocol of the experimental group included 6 weeks TRX for one hour 2 sessions/week. Shapiro Wilk test one-way ANCOVA test were used for normality of datas and statistical analysis of datas (P≤0.05), respectively. Results: Findings to this study show that six weeks of TRX exercises had a positive effect on enhancing the upper body strength, improvements in agility and a small increasing in the lower body strength in older women. Conclusion: Therefore, we conclude that physical activities using TRX methods can be useful for older adults resulting in the increasing muscle strength and improving the agility. So, TRX trainers and exercise physiologists are suggested to use TRX exercises to improve the total physical fitness in elderlies.