The present study was conducted in order to determine the effect of combined endurance-resistance exercises and consumption of nettle extract on adipsin indices in obese women. The worldwide prevalence of overweight and obesity has doubled since 1980, such that approximately one-third of the world's population is now classified as overweight or obese (Study, 2017). Obesity negatively affects almost all physiological functions of the body and poses a significant threat to public health. In 2013, the American Medical Association has introduced obesity as a metabolic disease to emphasize the importance of public health. In this regard, it can be said that obesity is a multifactorial and complex metabolic disease with epigenetic interactions.The statistical population of the current study consisted of obese women witThe worldwide prevalence of overweight and obesity has doubled since 1980, such that approximately one-third of the world's population is now classified as overweight or obese (Study, 2017). Obesity negatively affects almost all physiological functions of the body and poses a significant threat to public health. In 2013, the American Medical Association has introduced obesity as a metabolic disease to emphasize the importance of public health. In this regard, it can be said that obesity is a multifactorial and complex metabolic disease with epigenetic interactions.h a body mass index above 30 in the age range of 30-40 years. 40 people were randomly selected from the statistical population and eligible people to enter the research and were divided into four groups: exercise (10 people), supplement (10 people), exercise and supplement (10 people) and control (10 people). The program of exercises was three sessions a week for 8 weeks, which was done in the form of endurance and resistance exercises according to the protocol in each session at the same time. Nettle extract was also given to the subjects daily to consume according to the instructions. Blood samples before and after the completion of 8 weeks were taken from the brachial vein under fasting conditions 24 hours before the start of the protocol and 48 hours after the completion of the protocol. The amount of adipsin was evaluated by ELISA method using their special kits. The results showed that exercise, supplementation, and the combination of exercise and relaxation can reduce the inflammatory indices of adipsin, but the most effective of these indices was as a result of combined exercises with the use of nettle supplements.