Background and Objectives: The purpose of this study was to evaluate the effect of pre-treatment of exercise and Ginseng supplementation on improving the balance of male Wistar rats in Parkinson's disease model .

Materials and Methods: 50 male rats were divided into 5 groups of 10 (sham, control, optional exercise, complementary ginseng, and combined group). Initially, the Rotarod balance test and the apomorphine diagnostic test (to confirm parkinsonism) were conducted on all groups. Subsequently, the experimental groups underwent their interventions for one month; the exercise group used a wheelchair-equipped cushion, and the complementary ginseng group received supplementation orally. The combined group received both complementary ginseng supplementation and the wheelchair intervention . The first post-test was conducted 48 hours after the last session of Parkinson's Modeling Surgery (using 6-OHDA) and placebo on the groups .

Results: One-way ANOVA was used to measure changes in the Rotarod test. Comparing the first post-test, significant differences were observed in the Rotarod balance test between the first post-test and the control group, the optional exercise group, the sham group, and the complementary group. Additionally, significant differences were found between the combined group and the control group in the second post-test. Noteworthy differences were also observed between the second post-test of the combined group and the sham group, the control group, the optional exercise group, and the ginseng supplement group .

Discussion and Conclusion: Ginseng supplementation and optional voluntary exercise appear to enhance the performance of Parkinson's disease induction in animal models of Parkinson's disease .